GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs4409766 | 1 | rs1004467 | chr10:104594507 | SFXN2 | chr10:104474298-104498946:+ | -0.22 | -4.49 | 7.77E-6 | Hypertension;Systolic blood pressure;Diastolic blood pressure |
| BRCA | cis | rs7833268 | 1 | rs10046678 | chr8:23816123 | CHMP7 | chr8:23101150-23119512:+ | -0.16 | -3.42 | 0.000658 | Subcutaneous adipose tissue |
| BRCA | cis | rs7833268 | 1 | rs10046678 | chr8:23816123 | ENTPD4 | chr8:23243442-23315244:- | -0.13 | -3.44 | 0.000599 | Subcutaneous adipose tissue |
| BRCA | cis | rs7833268 | 1 | rs10046678 | chr8:23816123 | RHOBTB2 | chr8:22844930-22877710:+ | -0.15 | -4.01 | 6.55E-5 | Subcutaneous adipose tissue |
| BRCA | cis | rs13010639 | 1 | rs1004868 | chr2:231038910 | SP110 | chr2:231033645-231084827:- | 0.21 | 4.08 | 4.79E-5 | Obesity-related traits |
| BRCA | cis | rs13010639 | 1 | rs1004869 | chr2:231039271 | SP110 | chr2:231033645-231084827:- | 0.21 | 4.05 | 5.42E-5 | Obesity-related traits |
| BRCA | cis | rs10043228 | 1 | rs10051240 | chr5:115569931 | COMMD10 | chr5:115420727-115628978:+ | 0.21 | 4.49 | 7.77E-6 | Asthma or chronic obstructive pulmonary disease |
| BRCA | cis | rs10461617 | 1 | rs10051747 | chr5:56083289 | C5orf35 | chr5:56205103-56213010:+ | 0.75 | 18.4 | 7.24E-66 | Type 2 diabetes |
| BRCA | cis | rs6452524 | 1 | rs10055844 | chr5:82437095 | XRCC4 | chr5:82373317-82649577:+ | -0.12 | -3.45 | 0.000584 | Hypertension |
| BRCA | cis | rs10043228 | 1 | rs10055868 | chr5:115471612 | COMMD10 | chr5:115420727-115628978:+ | 0.24 | 5.08 | 4.56E-7 | Asthma or chronic obstructive pulmonary disease |
| BRCA | cis | rs6452524 | 1 | rs10055948 | chr5:82439256 | XRCC4 | chr5:82373317-82649577:+ | -0.12 | -3.54 | 0.000421 | Hypertension |
| BRCA | cis | rs10043228 | 1 | rs10062350 | chr5:115453497 | COMMD10 | chr5:115420727-115628978:+ | 0.23 | 4.57 | 5.52E-6 | Asthma or chronic obstructive pulmonary disease |
| BRCA | cis | rs10043228 | 1 | rs10066259 | chr5:115451892 | COMMD10 | chr5:115420727-115628978:+ | 0.21 | 4.16 | 3.51E-5 | Asthma or chronic obstructive pulmonary disease |
| BRCA | cis | rs2840044 | 1 | rs10068 | chr17:33901965 | SLFN12L | chr17:33801926-33864880:- | 0.09 | 4.83 | 1.57E-6 | Response to radiotherapy in cancer (late toxicity) |
| BRCA | cis | rs10043228 | 1 | rs10073364 | chr5:115592582 | COMMD10 | chr5:115420727-115628978:+ | 0.22 | 4.57 | 5.42E-6 | Asthma or chronic obstructive pulmonary disease |